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In April 2013, the workgroup's research was presented at an in-person meeting of the multidisciplinary workgroup members.
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The outcome of the literature review informed development of background materials, including tables of evidence from peer-reviewed publications summarizing the type of study (e.g., randomized controlled trial or case series), study population and setting, treatments or other interventions, outcome measures assessed, reported findings, and weaknesses and biases in study design and analysis. These reviews also focused on four principal outcomes of STD therapy for each individual disease or infection: 1) treatment of infection based on microbiologic eradication 2) alleviation of signs and symptoms 3) prevention of sequelae 4) prevention of transmission, including advantages such as cost-effectiveness and other advantages (e.g., single-dose formulations and directly observed therapy) and disadvantages (e.g., side effects) of specific regimens. To answer these questions and synthesize new information available since publication of the 2010 Guidelines, workgroup members collaborated with CDC staff to conduct a systematic literature review using an extensive MEDLINE database evidence-based approach (e.g., using published abstracts and peer-reviewed journal articles).
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In 2012, CDC staff and workgroup members were charged with identifying key questions regarding treatment and clinical management that were not addressed in the 2010 STD Treatment Guidelines ( 1). All potential conflicts of interest are listed at the end of the workgroup member section. All workgroup members disclosed potential conflicts of interest several members of the workgroup acknowledged receiving financial support for clinical research from commercial companies.
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Members of the multidisciplinary workgroup included representatives from federal, state, and local health departments public- and private-sector clinical providers clinical and basic science researchers and numerous professional organizations. These guidelines were developed by CDC staff and an independent workgroup for which members were selected on the basis of their expertise in the clinical management of STDs. These guidelines focus on treatment and counseling and do not address other community services and interventions that are essential to STD/HIV prevention efforts.
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These guidelines are applicable to any patient-care setting that serves persons at risk for STDs, including family-planning clinics, HIV-care clinics, correctional health-care settings, private physicians' offices, Federally Qualified Health Centers (FQHCs), and other primary-care facilities. These recommendations should be regarded as a source of clinical guidance rather than prescriptive standards health-care providers should always consider the clinical circumstances of each person in the context of local disease prevalence. This document updates CDC's Sexually Transmitted Diseases Treatment Guidelines, 2010 ( 1). Although these guidelines emphasize treatment, prevention strategies and diagnostic recommendations also are discussed. These guidelines for the treatment of STDs are intended to assist with that effort. Physicians and other health-care providers play a critical role in preventing and treating STDs. The term sexually transmitted diseases (STDs) refers to a variety of clinical syndromes and infections caused by pathogens that can be acquired and transmitted through sexual activity. Physicians and other health-care providers can use these guidelines to assist in the prevention and treatment of STDs. These updated guidelines discuss 1) alternative treatment regimens for Neisseria gonorrhoeae 2) the use of nucleic acid amplification tests for the diagnosis of trichomoniasis 3) alternative treatment options for genital warts 4) the role of Mycoplasma genitalium in urethritis/cervicitis and treatment-related implications 5) updated HPV vaccine recommendations and counseling messages 6) the management of persons who are transgender 7) annual testing for hepatitis C in persons with HIV infection 8) updated recommendations for diagnostic evaluation of urethritis and 9) retesting to detect repeat infection. The information in this report updates the Sexually Transmitted Diseases Treatment Guidelines, 2010 (MMWR Recomm Rep 2010 59 ). These guidelines for the treatment of persons who have or are at risk for sexually transmitted diseases (STDs) were updated by CDC after consultation with a group of professionals knowledgeable in the field of STDs who met in Atlanta on April 30–May 2, 2013.
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National Center for HIV/AIDS, Viral Hepatitis, STD, and TB PreventionĢ Emory University, Atlanta, Georgia Summary Please note: An erratum has been published for this article. Sexually Transmitted Diseases Treatment Guidelines, 2015